Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans

Aggregation of amyloid-β (Aβ) as toxic oligomers and amyloid plaques within the brain appears to be the pathogenic event that initiates Alzheimer's disease (AD) lesions. One therapeutic strategy has been to reduce Aβ levels to limit its accumulation. Activation of certain neurotransmitter recep...

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Hauptverfasser: Cirrito, John R., Disabato, Brianne M., Restivo, Jessica L., Verges, Deborah K., Goebel, Whitney D., Sathyan, Anshul, Hayreh, Davinder, D'Angelo, Gina, Benzinger, Tammie, Yoon, Hyejin, Kim, Jungsu, Morris, John C., Mintun, Mark A., Sheline, Yvette I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169155/
https://ncbi.nlm.nih.gov/pubmed/21873225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107411108
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