Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans

Aggregation of amyloid-β (Aβ) as toxic oligomers and amyloid plaques within the brain appears to be the pathogenic event that initiates Alzheimer's disease (AD) lesions. One therapeutic strategy has been to reduce Aβ levels to limit its accumulation. Activation of certain neurotransmitter recep...

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Detalhes bibliográficos
Main Authors: Cirrito, John R., Disabato, Brianne M., Restivo, Jessica L., Verges, Deborah K., Goebel, Whitney D., Sathyan, Anshul, Hayreh, Davinder, D'Angelo, Gina, Benzinger, Tammie, Yoon, Hyejin, Kim, Jungsu, Morris, John C., Mintun, Mark A., Sheline, Yvette I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169155/
https://ncbi.nlm.nih.gov/pubmed/21873225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107411108
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