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Insight into G-DNA Structural Polymorphism and Folding from Sequence and Loop Connectivity through Free Energy Analysis

[Image: see text] The lengths of G-tracts and their connecting loop sequences determine G-quadruplex folding and stability. Complete understanding of the sequence–structure relationships remains elusive. Here, single-loop G-quadruplexes were investigated using explicit solvent molecular dynamics (MD...

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Hlavní autoři: Cang, Xiaohui, Šponer, Jiří, Cheatham, III, Thomas E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2011
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3168932/
https://ncbi.nlm.nih.gov/pubmed/21761922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja107805r
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