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High fat diet increases and the polyphenol, S17834, decreases acetylation of the SirT1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice
Our purpose was to determine if high fat diet and treatment with a polyphenol regulates acetylation of lysine-382 of p53, the site regulated by sirtuin-1, and apoptosis in the endothelium of the atherosclerotic lesion-prone mouse aortic arch. In cultured endothelial cells two atherogenic stimuli, hy...
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Glavni autori: | , , , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
Izdano: |
2011
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Teme: | |
Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3168693/ https://ncbi.nlm.nih.gov/pubmed/21654327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0b013e3182239eb7 |
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