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The control of trunk Hox specificity and activity by Extradenticle

We characterize a 37-bp element (fkh[250]) derived from the fork head (fkh) gene, a natural target of the Hox gene Sex combs reduced (Scr). In vitro, Scr cooperatively binds to this DNA with the Hox cofactor Extradenticle (Exd), and the activation of this enhancer in vivo requires Scr and exd. Other...

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Autori principali: Ryoo, Hyung Don, Mann, Richard S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC316852/
https://ncbi.nlm.nih.gov/pubmed/10398683
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