Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress
Hydrogen peroxide (H(2)O(2)), a reactive oxygen species (ROS), is known to induce oxidative stress and apoptosis. U937 cells treated with H(2)O(2) were shown to produce high molecular weight (HMW) DNA fragments ∼50 to 100 kb in size in <1 min. The formation of these HMW DNA fragments is reversible a...
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| 出版年: | Genes Dev |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
1999
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316815/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10385624/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.12.1553 |
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