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Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress

Hydrogen peroxide (H(2)O(2)), a reactive oxygen species (ROS), is known to induce oxidative stress and apoptosis. U937 cells treated with H(2)O(2) were shown to produce high molecular weight (HMW) DNA fragments ∼50 to 100 kb in size in <1 min. The formation of these HMW DNA fragments is reversible a...

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Udgivet i:Genes Dev
Principais autores: Li, Tsai-Kun, Chen, Allen Y., Yu, Chiang, Mao, Yong, Wang, Huimin, Liu, Leroy F.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1999
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316815/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10385624/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.12.1553
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