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Putative rhesus macaque germline predecessors of human broadly HIV-neutralizing antibodies: differences from the human counterparts and implications for HIV-1 vaccine development

Broadly neutralizing antibodies (bnAbs) are likely to be a key component of protective immunity conferred by an effective HIV-1 vaccine. We and others have reported that putative human germline predecessors of known human bnAbs lack measurable binding to HIV-1 envelope glycoproteins (Env), which cou...

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Bibliografiske detaljer
Main Authors: Yuan, Tingting, Li, Jingjing, Zhang, Yu, Wang, Yanping, Streaker, Emily, Dimitrov, Dimiter S., Zhang, Mei-Yun
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167946/
https://ncbi.nlm.nih.gov/pubmed/21807049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.07.046
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