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Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis

The DMP1 transcription factor induces the ARF tumor suppressor gene in mouse fibroblasts, leading to cell cycle arrest in a p53-dependent manner. We disrupted sequences encoding the DNA-binding domain of DMP1 in mouse embryonic stem cells and derived animals lacking the functional protein. DMP1-null...

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Published in:Genes Dev
Main Authors: Inoue, Kazushi, Wen, Renren, Rehg, Jerold E., Adachi, Masashi, Cleveland, John L., Roussel, Martine F., Sherr, Charles J.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2000
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Research Paper
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316790/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10898794/
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