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Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase
Avian influenza A viruses often do not propagate efficiently in mammalian cells. The viral polymerase protein PB2 is important for this host restriction, with amino-acid polymorphisms at residue 627 and other positions acting as ‘signatures’ of avian- or human-adapted viruses. Restriction is hypothe...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Society for General Microbiology
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3167894/ https://ncbi.nlm.nih.gov/pubmed/21471313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.031492-0 |
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