Altered Development of NKT Cells, γδ T Cells, CD8 T Cells and NK Cells in a PLZF Deficient Patient

In mice, the transcription factor, PLZF, controls the development of effector functions in invariant NKT cells and a subset of NKT cell-like, γδ T cells. Here, we show that in human lymphocytes, in addition to invariant NKT cells, PLZF was also expressed in a large percentage of CD8+ and CD4+ T cell...

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Main Authors: Eidson, Maggie, Wahlstrom, Justin, Beaulieu, Aimee M., Zaidi, Bushra, Carsons, Steven E., Crow, Peggy K., Yuan, Jianda, Wolchok, Jedd D., Horsthemke, Bernhard, Wieczorek, Dagmar, Sant'Angelo, Derek B.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167854/
https://ncbi.nlm.nih.gov/pubmed/21915328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024441
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