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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

The multisubunit eukaryotic translation initiation factor (eIF) 4F recruits 40S ribosomal subunits to the 5′ end of mRNA. The eIF4F subunit eIF4E interacts directly with the mRNA 5′ cap structure. Assembly of the eIF4F complex is inhibited by a family of repressor polypeptides, the eIF4E-binding pro...

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Publicat a:Genes Dev
Autors principals: Gingras, Anne-Claude, Gygi, Steven P., Raught, Brian, Polakiewicz, Roberto D., Abraham, Robert T., Hoekstra, Merl F., Aebersold, Ruedi, Sonenberg, Nahum
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 1999
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316780/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10364159/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.11.1422
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