p53-Mediated apoptosis is attenuated in Werner syndrome cells

The WRN DNA helicase is a member of the DExH-containing DNA helicase superfamily that includes XPB, XPD, and BLM. Mutations in WRN are found in patients with the premature aging and cancer susceptibility syndrome known as Werner syndrome (WS). p53 binds to the WRN protein in vivo and in vitro throug...

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Autors principals: Spillare, Elisa A., Robles, Ana I., Wang, Xin Wei, Shen, Jiang-Cheng, Yu, Chang-Eu, Schellenberg, Gerard D., Harris, Curtis C.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 1999
Matèries:
Research Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC316776/
https://ncbi.nlm.nih.gov/pubmed/10364153
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