A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

An insulin receptor-like signaling pathway regulates Caenorhabditis elegans metabolism, development, and longevity. Inactivation of the insulin receptor homolog DAF-2, the AGE-1 PI3K, or the AKT-1 and AKT-2 kinases causes a developmental arrest at the dauer stage. A null mutation in the daf-16 Fork...

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Detalles Bibliográficos

Publicado en:	Genes Dev
Principais autores:	Paradis, Suzanne, Ailion, Michael, Toker, Alex, Thomas, James H., Ruvkun, Gary
Formato:	Artigo
Idioma:	Inglês
Publicado:	Cold Spring Harbor Laboratory Press 1999
Assuntos:	Research Paper
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316759/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10364160/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.11.1438
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