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Structural variants of IFNα preferentially promote antiviral functions

IFNα, a cytokine with multiple functions in innate and adaptive immunity and a potent inhibitor of HIV, exerts antiviral activity, in part, by enhancing apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3 (APOBEC3) family members. Although IFNα therapy is associated with reduced viral...

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Detalhes bibliográficos
Main Authors: Vázquez, Nancy, Schmeisser, Hana, Dolan, Michael A., Bekisz, Joseph, Zoon, Kathryn C., Wahl, Sharon M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167361/
https://ncbi.nlm.nih.gov/pubmed/21757613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-325027
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