Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells

The role of Wnt signaling in hematopoietic stem cell fate decisions remains controversial. We elected to dysregulate Wnt signaling from the perspective of the stem cell niche by expressing the pan Wnt inhibitor, Wnt inhibitory factor 1 (Wif1), specifically in osteoblasts. Here we report that osteobl...

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Bibliografiske detaljer
Main Authors: Schaniel, Christoph, Sirabella, Dario, Qiu, Jiajing, Niu, Xiaohong, Lemischka, Ihor R., Moore, Kateri A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2011
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167356/
https://ncbi.nlm.nih.gov/pubmed/21652676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-305664
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