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Crystal structure of the human Pax6 paired domain–DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding

Pax6, a transcription factor containing the bipartite paired DNA-binding domain, has critical roles in development of the eye, nose, pancreas, and central nervous system. The 2.5 Å structure of the human Pax6 paired domain with its optimal 26-bp site reveals extensive DNA contacts from the amino-ter...

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Udgivet i:Genes Dev
Principais autores: Xu, H. Eric, Rould, Mark A., Xu, Wenqing, Epstein, Jonathan A., Maas, Richard L., Pabo, Carl O.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1999
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316729/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10346815/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.10.1263
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