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The Stabilizing Effect of Moisture on the Solid-State Degradation of Gabapentin
Gabapentin is known to undergo intramolecular cyclization to form a lactam (gaba-l) with concomitant loss of water. Gabapentin was milled in a planetary mill for 15–60 min. Unmilled and milled gabapentin were stored at 50°C with relative humidity ranged between 5% and 90%. The unmilled and milled sa...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3167261/ https://ncbi.nlm.nih.gov/pubmed/21744168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-011-9652-8 |
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