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Multi-conformation 3D QSAR study of benzenesulfonyl-pyrazol-ester compounds and their analogs as cathepsin B inhibitors

Cathepsin B has been found being responsible for many human diseases. Inhibitors of cathepsin B, a ubiquitous lysosomal cysteine protease, have been developed as a promising treatment for human diseases resulting from malfunction and over-expression of this enzyme. Through a high throughput screenin...

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Detalhes bibliográficos
Main Authors: Zhou, Zhigang, Wang, Yanli, Bryant, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167229/
https://ncbi.nlm.nih.gov/pubmed/21798778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2011.06.013
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