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Synthesis of dehydrodipeptide esters and their evaluation as inhibitors of cathepsin C

The procedures for the synthesis of esters of dehydropeptides containing C-terminal (Z)-dehydrophenylalanine and dehydroalanine have been elaborated. These esters appeared to be moderate or weak inhibitors of cathepsin C, with some of them exhibiting slow-binding behavior. As shown by molecular mode...

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Bibliografiske detaljer
Udgivet i:Med Chem Res
Main Authors: Makowski, Maciej, Lenartowicz, Paweł, Oszywa, Bartosz, Jewgiński, Michał, Pawełczak, Małgorzata, Kafarski, Paweł
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500854/
https://ncbi.nlm.nih.gov/pubmed/26190908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00044-015-1366-0
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