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Synthesis of dehydrodipeptide esters and their evaluation as inhibitors of cathepsin C
The procedures for the synthesis of esters of dehydropeptides containing C-terminal (Z)-dehydrophenylalanine and dehydroalanine have been elaborated. These esters appeared to be moderate or weak inhibitors of cathepsin C, with some of them exhibiting slow-binding behavior. As shown by molecular mode...
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| Udgivet i: | Med Chem Res |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Springer US
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4500854/ https://ncbi.nlm.nih.gov/pubmed/26190908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00044-015-1366-0 |
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