FAM190A Rearrangements Provide a Multitude of Individualized Tumor Signatures and Neo-antigens in Cancer

We found FAM190A transcripts to have internal rearrangements in 40% (19/48) of unselected human cancers. Most of these tumors (84%) had in-frame structures, 94% of which involved deletion of exon 9. The FAM190A gene is located at 4q22.1 in a region of common fragility, FRA4F. Although normally stabl...

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Autori principali: Scrimieri, Francesca, Calhoun, Eric S., Patel, Kalpesh, Gupta, Rigu, Huso, David L., Hruban, Ralph H., Kern, Scott E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2011
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167148/
https://ncbi.nlm.nih.gov/pubmed/21378412
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