NLRX1 protein attenuates inflammatory responses to virus infection by interfering with the RIG-I-MAVS signaling pathway and TRAF6 ubiquitin ligase

The nucleotide-binding domain and leucine-rich repeat containing (NLR) proteins regulate innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory roles are not well defined. We showed Nlrx1(−/−) mice exhibited increased expression of antiviral signaling molecules I...

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Main Authors: Allen, Irving C., Moore, Chris B., Schneider, Monika, Lei, Yu, Davis, Beckley K., Scull, Margaret A., Gris, Denis, Roney, Kelly E., Zimmermann, Albert G., Bowzard, John B., Ranjan, Priya, Monroe, Kathryn M., Pickles, Raymond J., Sambhara, Suryaprakash, Ting, Jenny P.Y.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166771/
https://ncbi.nlm.nih.gov/pubmed/21703540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.03.026
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