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Chemoenzymatic Synthesis of Glycosylphosphatidylinositol-Anchored Glycopeptides

MUC1 glycopeptide was efficiently coupled to glycosylphosphatidylinositol (GPI) derivatives by sortase A (SrtA), verifying that SrtA can accept sterically hindered glycopeptide as substrate for ligation with GPIs. This work has established a practical method for the chemoenzymatic synthesis of GPI-l...

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Detalhes bibliográficos
Main Authors: Wu, Zhimeng, Guo, Xueqing, Guo, Zhongwu
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166627/
https://ncbi.nlm.nih.gov/pubmed/20574591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0cc00828a
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