Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation

Cancer-causing mutations often arise from gross chromosomal rearrangements (GCRs) such as translocations, which involve genetic exchange between nonhomologous chromosomes. Here we show that murine Brca2 has an essential function in suppressing GCR formation after chromosome breakage. Cells that harb...

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Détails bibliographiques
Auteurs principaux: Yu, Veronica P.C.C., Koehler, Michael, Steinlein, Claus, Schmid, Michael, Hanakahi, Leslyn A., van Gool, Alain J., West, Stephen C., Venkitaraman, Ashok R.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2000
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC316655/
https://ncbi.nlm.nih.gov/pubmed/10837032
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