Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation

Cancer-causing mutations often arise from gross chromosomal rearrangements (GCRs) such as translocations, which involve genetic exchange between nonhomologous chromosomes. Here we show that murine Brca2 has an essential function in suppressing GCR formation after chromosome breakage. Cells that harb...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Yu, Veronica P.C.C., Koehler, Michael, Steinlein, Claus, Schmid, Michael, Hanakahi, Leslyn A., van Gool, Alain J., West, Stephen C., Venkitaraman, Ashok R.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2000
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC316655/
https://ncbi.nlm.nih.gov/pubmed/10837032
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker