Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation

Cancer-causing mutations often arise from gross chromosomal rearrangements (GCRs) such as translocations, which involve genetic exchange between nonhomologous chromosomes. Here we show that murine Brca2 has an essential function in suppressing GCR formation after chromosome breakage. Cells that harb...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Yu, Veronica P.C.C., Koehler, Michael, Steinlein, Claus, Schmid, Michael, Hanakahi, Leslyn A., van Gool, Alain J., West, Stephen C., Venkitaraman, Ashok R.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2000
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC316655/
https://ncbi.nlm.nih.gov/pubmed/10837032
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados