Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src−/− mutant mice

The Src tyrosine kinase has been implicated in a wide variety of signal transduction pathways, yet despite the nearly ubiquitous expression of c-src, src−/− mice show only one major phenotype—osteopetrosis caused by an intrinsic defect in osteoclasts, the cells responsible for resorbing bone. To exp...

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Pubblicato in:	Genes Dev
Autori principali:	Schwartzberg, Pamela L., Xing, Lianping, Hoffmann, Oskar, Lowell, Clifford A., Garrett, Lisa, Boyce, Brendan F., Varmus, Harold E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 1997
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316651/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9353253/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.11.21.2835
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