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Synthesis and Characterization of Lipid-Polymer Hybrid Nanoparticles with pH-Triggered PEG Shedding
Novel lipid-polymer hybrid nanoparticles are designed with a poly(ethylene glycol) coating that is shed in response to a low pH trigger. This allows the nanoparticles to be stable during systemic circulation and at neutral pH, but destabilize and fuse with lipid membranes in acidic environments. The...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3166210/ https://ncbi.nlm.nih.gov/pubmed/21806013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/la202123e |
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