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Targeting Epigenetic Regulation of miR-34a for Treatment of Pancreatic Cancer by Inhibition of Pancreatic Cancer Stem Cells

BACKGROUND: MicroRNA-34a (miR-34a) is a transcriptional target of p53 and is down-regulated in pancreatic cancer. This study aimed to investigate the functional significance of miR-34a in pancreatic cancer progression through its epigenetic restoration with chromatin modulators, demethylating agent...

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Bibliografiske detaljer
Main Authors: Nalls, Dara, Tang, Su-Ni, Rodova, Marianna, Srivastava, Rakesh K., Shankar, Sharmila
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166078/
https://ncbi.nlm.nih.gov/pubmed/21909380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024099
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