Lung-specific loss of the laminin α3 subunit confers resistance to mechanical injury

Laminins are heterotrimeric glycoproteins of the extracellular matrix that are secreted by epithelial cells and which are crucial for the normal structure and function of the basement membrane. We have generated a mouse harboring a conditional knockout of α3 laminin (Lama3(fl/fl)), one of the main l...

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Autors principals: Urich, Daniela, Eisenberg, Jessica L., Hamill, Kevin J., Takawira, Desire, Chiarella, Sergio E., Soberanes, Saul, Gonzalez, Angel, Koentgen, Frank, Manghi, Tomas, Hopkinson, Susan B., Misharin, Alexander V., Perlman, Harris, Mutlu, Gokhan M., Budinger, G. R. Scott, Jones, Jonathan C. R.
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166037/
https://ncbi.nlm.nih.gov/pubmed/21878500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.080911
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