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Differential effect of opioid and cannabinoid receptor blockade on heroin-seeking reinstatement and cannabinoid substitution in heroin-abstinent rats

BACKGROUND AND PURPOSE: Opioids and cannabinoids interact in drug addiction and relapse. We investigated the effect of the opioid receptor antagonist naloxone and/or the cannabinoid CB(1) receptor antagonist rimonabant on cannabinoid-induced reinstatement of heroin seeking and on cannabinoid substit...

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Autori principali: Fattore, L, Spano, MS, Melis, V, Fadda, P, Fratta, W
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165962/
https://ncbi.nlm.nih.gov/pubmed/21518339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01459.x
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