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Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast

In budding yeast, ubiquitination of the cyclin-dependent kinase (Cdk) inhibitor Sic1 is catalyzed by the E2 ubiquitin conjugating enzyme Cdc34 in conjunction with an E3 ubiquitin ligase complex composed of Skp1, Cdc53 and the F-box protein, Cdc4 (the SCF(Cdc4) complex). Skp1 binds a motif called the...

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Published in:Genes Dev
Main Authors: Patton, E. Elizabeth, Willems, Andrew R., Sa, Danne, Kuras, Laurent, Thomas, Dominique, Craig, Karen L., Tyers, Mike
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 1998
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Research Paper
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316590/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9499404/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.5.692
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