Hepatitis C Virus Stimulates the Phosphatidylinositol 4-Kinase III Alpha-Dependent Phosphatidylinositol 4-Phosphate Production That Is Essential for Its Replication

Phosphatidylinositol 4-kinase III alpha (PI4KA) is an essential cofactor of hepatitis C virus (HCV) replication. We initiated this study to determine whether HCV directly engages PI4KA to establish its replication. PI4KA kinase activity was found to be absolutely required for HCV replication using a...

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Detalles Bibliográficos
Main Authors: Berger, Kristi L., Kelly, Sean M., Jordan, Tristan X., Tartell, Michael A., Randall, Glenn
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
Assuntos:
Cellular Response to Infection
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165839/
https://ncbi.nlm.nih.gov/pubmed/21697487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00059-11
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