Hepatitis C Virus Stimulates the Phosphatidylinositol 4-Kinase III Alpha-Dependent Phosphatidylinositol 4-Phosphate Production That Is Essential for Its Replication

Phosphatidylinositol 4-kinase III alpha (PI4KA) is an essential cofactor of hepatitis C virus (HCV) replication. We initiated this study to determine whether HCV directly engages PI4KA to establish its replication. PI4KA kinase activity was found to be absolutely required for HCV replication using a...

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Detalhes bibliográficos
Main Authors: Berger, Kristi L., Kelly, Sean M., Jordan, Tristan X., Tartell, Michael A., Randall, Glenn
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165839/
https://ncbi.nlm.nih.gov/pubmed/21697487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00059-11
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