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The Papillomavirus E1 Helicase Activates a Cellular DNA Damage Response in Viral Replication Foci

The papillomavirus E1 and E2 proteins are essential for viral genome replication. E1 is a helicase that unwinds the viral origin and recruits host cellular factors to replicate the viral genome. E2 is a transcriptional regulator that helps recruit the E1 helicase to the origin and also plays a role...

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Autors principals: Sakakibara, Nozomi, Mitra, Ruchira, McBride, Alison A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165833/
https://ncbi.nlm.nih.gov/pubmed/21734054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00541-11
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