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Mammalian Orthoreovirus Escape from Host Translational Shutoff Correlates with Stress Granule Disruption and Is Independent of eIF2α Phosphorylation and PKR

In response to mammalian orthoreovirus (MRV) infection, cells initiate a stress response that includes eIF2α phosphorylation and protein synthesis inhibition. We have previously shown that early in infection, MRV activation of eIF2α phosphorylation results in the formation of cellular stress granule...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Qin, Qingsong, Carroll, Kate, Hastings, Craig, Miller, Cathy L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165827/
https://ncbi.nlm.nih.gov/pubmed/21715487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01831-10
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