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Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon–exon junctions

We provide direct evidence that pre-mRNA splicing alters mRNP protein composition. Using a novel in vitro cross-linking approach, we detected several proteins that associate with mRNA exon–exon junctions only as a consequence of splicing. Immunoprecipitation experiments suggested that these proteins...

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Main Authors: Le Hir, Hervé, Moore, Melissa J., Maquat, Lynne E.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2000
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC316578/
https://ncbi.nlm.nih.gov/pubmed/10809668
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