Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon–exon junctions

We provide direct evidence that pre-mRNA splicing alters mRNP protein composition. Using a novel in vitro cross-linking approach, we detected several proteins that associate with mRNA exon–exon junctions only as a consequence of splicing. Immunoprecipitation experiments suggested that these proteins...

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Pubblicato in:	Genes Dev
Autori principali:	Le Hir, Hervé, Moore, Melissa J., Maquat, Lynne E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 2000
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316578/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10809668/
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