1,25-Dihydroxyvitamin D(3) Ameliorates Th17 Autoimmunity via Transcriptional Modulation of Interleukin-17A

A new class of inflammatory CD4(+) T cells that produce interleukin-17 (IL-17) (termed Th17) has been identified, which plays a critical role in numerous inflammatory conditions and autoimmune diseases. The active form of vitamin D, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], has a direct repressi...

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Detalhes bibliográficos
Main Authors: Joshi, Sneha, Pantalena, Luiz-Carlos, Liu, Xikui K., Gaffen, Sarah L., Liu, Hong, Rohowsky-Kochan, Christine, Ichiyama, Kenji, Yoshimura, Akihiko, Steinman, Lawrence, Christakos, Sylvia, Youssef, Sawsan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165548/
https://ncbi.nlm.nih.gov/pubmed/21746882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05020-11
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