eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine–nucleotide exchange

eIF2B is a heteropentameric guanine-nucleotide exchange factor essential for protein synthesis initiation in eukaryotes. Its activity is inhibited in response to starvation or stress by phosphorylation of the α subunit of its substrate, translation initiation factor eIF2, resulting in reduced rates...

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Detalles Bibliográficos

Publicado en:	Genes Dev
Autores principales:	Pavitt, Graham D., Ramaiah, Kolluru V.A., Kimball, Scot R., Hinnebusch, Alan G.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Cold Spring Harbor Laboratory Press 1998
Materias:	Research Paper
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316533/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9472020/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.4.514
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