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4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

Growth factors and hormones activate protein translation by phosphorylation and inactivation of the translational repressors, the eIF4E-binding proteins (4E-BPs), through a wortmannin- and rapamycin-sensitive signaling pathway. The mechanism by which signals emanating from extracellular signals lead...

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Udgivet i:Genes Dev
Principais autores: Gingras, Anne-Claude, Kennedy, Scott G., O’Leary, Maura A., Sonenberg, Nahum, Hay, Nissim
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1998
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316523/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9472019/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.4.502
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