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A prolonged and exaggerated wound response with elevated ODC activity mimics early tumor development
Induction of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, in ODC transgenic skin stimulates epidermal proliferation but not hyperplasia, activates underlying stromal cells and promotes skin tumorigenesis following a single subthreshold dose of a carcinogen. Because chronic...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3165128/ https://ncbi.nlm.nih.gov/pubmed/21730362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr129 |
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