CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression

Genome-wide association studies have linked lung cancer risk with a region of chromosome 15q25.1 containing CHRNA3, CHRNA5 and CHRNB4 encoding α3, α5 and β4 subunits of nicotinic acetylcholine receptors (nAChR), respectively. One of the strongest associations was observed for a non-silent single-nuc...

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Detalles Bibliográficos
Main Authors: Krais, Annette M., Hautefeuille, Agnès H., Cros, Marie-Pierre, Krutovskikh, Vladimir, Tournier, Jean-Marie, Birembaut, Philippe, Thépot, Amélie, Paliwal, Anupam, Herceg, Zdenko, Boffetta, Paolo, Brennan, Paul, Hainaut, Pierre L.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
Assuntos:
Carcinogenesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165122/
https://ncbi.nlm.nih.gov/pubmed/21586512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr090
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