Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer

Nicotinic acetylcholine receptor (nAChR) genes form a highly conserved gene cluster at the lung cancer susceptibility locus 15q25.1. In this study, we show that the CHRN α 3 gene encoding nAChR α 3 subunit is a frequent target of aberrant DNA hypermethylation and silencing in lung cancer, whereas th...

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Detalhes bibliográficos
Principais autores: Paliwal, Anupam, Vaissière, Thomas, Krais, Annette, Cuenin, Cyrille, Cros, Marie-Pierre, Zaridze, David, Moukeria, Anush, Boffetta, Paolo, Hainaut, Pierre, Brennan, Paul, Herceg, Zdenko
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856323/
https://ncbi.nlm.nih.gov/pubmed/20332232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4550
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