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VALINE 44 AND VALINE 45 OF HUMAN GLUTATHIONE SYNTHETASE ARE KEY FOR SUBUNIT STABILITY AND NEGATIVE COOPERATIVITY
It was hypothesized that residues Val44 and Val45 serve as important residues for human glutathione synthetase (hGS) function and stability given their location at the dimer interface of this enzyme. Computational studies suggest that mutation at Val45 has more impact on the structure and stability...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3165040/ https://ncbi.nlm.nih.gov/pubmed/21683691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.06.034 |
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