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Presenilin 1 Regulates Homeostatic Synaptic Scaling Through Akt Signaling
Neurons in vivo and in vitro adapt to long-lasting changes in network activity by adjusting their synaptic strengths to stabilize firing rates. Here we show that homeostatic scaling of excitatory synapses is impaired in mouse hippocampal neurons lacking presenilin 1 (PS1(−/−)) or expressing a famili...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3164917/ https://ncbi.nlm.nih.gov/pubmed/21841774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2893 |
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