Impairment of Immunoproteasome Function by β5i/LMP7 Subunit Deficiency Results in Severe Enterovirus Myocarditis

Proteasomes recognize and degrade poly-ubiquitinylated proteins. In infectious disease, cells activated by interferons (IFNs) express three unique catalytic subunits β1i/LMP2, β2i/MECL-1 and β5i/LMP7 forming an alternative proteasome isoform, the immunoproteasome (IP). The in vivo function of IPs in...

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Autori principali: Opitz, Elisa, Koch, Annett, Klingel, Karin, Schmidt, Frank, Prokop, Stefan, Rahnefeld, Anna, Sauter, Martina, Heppner, Frank L., Völker, Uwe, Kandolf, Reinhard, Kuckelkorn, Ulrike, Stangl, Karl, Krüger, Elke, Kloetzel, Peter M., Voigt, Antje
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164653/
https://ncbi.nlm.nih.gov/pubmed/21909276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002233
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