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Kinetic, Crystallographic, and Mechanistic Characterization of TomN: Elucidation of a Function for a 4-Oxalocrotonate Tautomerase Homologue in the Tomaymycin Biosynthetic Pathway()

The biosynthesis of the C ring of the anti-tumor antibiotic agent, tomaymycin, is proposed to proceed through five enzyme-catalyzed steps from L-tyrosine. The genes encoding these enzymes have recently been cloned and their functions tentatively assigned, but there is limited biochemical evidence su...

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Bibliografski detalji
Glavni autori: Burks, Elizabeth A., Yan, Wupeng, Johnson, William H., Li, Wenzong, Schroeder, Gottfried K., Min, Christopher, Gerratana, Barbara, Zhang, Yan, Whitman, Christian P.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164527/
https://ncbi.nlm.nih.gov/pubmed/21809870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200947w
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