Constitutive and Chemokine-dependent Internalization and Recycling of CXCR7 in Breast Cancer Cells to Degrade Chemokine Ligands

CXCR7 is a receptor for chemokines including CXCL12 (SDF-1), a molecule that promotes tumor growth and metastasis in breast cancer and other malignancies. Building upon the recent observation that CXCR7 sequesters CXCL12, we investigated mechanisms for CXCR7-dependent uptake of chemokines. Breast ca...

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Main Authors: Luker, Kathryn E., Steele, Jessica M., Mihalko, Laura Anne, Ray, Paramita, Luker, Gary D.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164491/
https://ncbi.nlm.nih.gov/pubmed/20531309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.212
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