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Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity

The transition between the closed and open conformations of the Sec61 complex permits nascent protein insertion into the translocation channel. A critical event in this structural transition is the opening of the lateral translocon gate that is formed by four transmembrane (TM) spans (TM2, TM3, TM7,...

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Detalhes bibliográficos
Main Authors: Trueman, Steven F., Mandon, Elisabet C., Gilmore, Reid
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164448/
https://ncbi.nlm.nih.gov/pubmed/21737680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-01-0070
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