The SCF(β-TRCP)–ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro

Ubiquitin-mediated proteolysis has a central role in controlling the intracellular levels of several important regulatory molecules such as cyclins, CKIs, p53, and IκBα. Many diverse proinflammatory signals lead to the specific phosphorylation and subsequent ubiquitin-mediated destruction of the NF-...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Winston, Jeffrey T., Strack, Peter, Beer-Romero, Peggy, Chu, Claire Y., Elledge, Stephen J., Harper, J. Wade
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1999
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC316433/
https://ncbi.nlm.nih.gov/pubmed/9990852
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados