Production of 22-Hydroxy Metabolites of Vitamin D(3) by Cytochrome P450scc (CYP11A1) and Analysis of Their Biological Activities on Skin Cells

Cytochrome P450scc (CYP11A1) can hydroxylate vitamin D(3), producing 20S-hydroxyvitamin D(3) [20(OH)D(3)] and 20S,23-dihydroxyvitamin D(3) [20,23(OH)(2)D(3)] as the major metabolites. These are biologically active, acting as partial vitamin D receptor (VDR) agonists. Minor products include 17-hydrox...

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Detalhes bibliográficos
Main Authors: Tuckey, Robert C., Li, Wei, Shehabi, Haleem Z., Janjetovic, Zorica, Nguyen, Minh N., Kim, Tae-Kang, Chen, Jianjun, Howell, Danielle E., Benson, Heather A. E., Sweatman, Trevor, Baldisseri, Donna M., Slominski, Andrzej
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164270/
https://ncbi.nlm.nih.gov/pubmed/21677063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.040071
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