G(s)α enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice

The heterotrimeric G protein subunit G(s)α stimulates cAMP-dependent signaling downstream of G protein–coupled receptors. In this study, we set out to determine the role of G(s)α signaling in cells of the early osteoblast lineage in vivo by conditionally deleting G(s)α from osterix-expressing cells....

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Bibliografische gegevens
Hoofdauteurs: Wu, Joy Y., Aarnisalo, Piia, Bastepe, Murat, Sinha, Partha, Fulzele, Keertik, Selig, Martin K., Chen, Min, Poulton, Ingrid J., Purton, Louise E., Sims, Natalie A., Weinstein, Lee S., Kronenberg, Henry M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2011
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163961/
https://ncbi.nlm.nih.gov/pubmed/21804192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46406
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